The Bisulphite-Binding Power of the Blood in Cases of Epidemic Dropsy, Anæmia and Malaria and Its Possible Bearing on a Vitamin-B Deficiency
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چکیده
Peters and Sinclair (1933) have shown that in pigeons suffering from vitamin-B, deficiency the brain, when incubated with lactic acid, produced pyruvic acid in appreciable amount whereas when the brain of normal control birds is substituted this is not produced. Peters and Thompson (1934) further showed that pyruvic acid is probably a normal intermediary in the course of carbohydrate metabolism. In vitaminBt deficiency the metabolism of carbohydrate appears to be held up at the pyruvic acid stage; this leads to an accumulation of this substance. The exact precursor of pyruvic acid and its normal fate, oxidation or re-synthesis, is at present obscure. The fact however of its appearance in the tissue in this condition is all that need concern us in this preliminary report. This discovery led to an estimation of pyruvic acid in the blood of pigeons suffering from vitamin-B, deficiency. Thompson and Johnson (1935) found the blood pyruvate to be
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